Systems BiologybioRxivPreprint
Protein domain-based structural interfaces help interpret biologically-relevant interactions in the human interaction network.
Krishna Praneeth Kilambi, Qifang Xu, Guruharsha Kuthethur Gururaj…·Andreas Lehmann
The paper builds a structure-supported human interactome by integrating structural information with PPI data, identifying domain-domain and peptide-binding interactions to improve the resolution and biological relevance of the network.
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