Steven A. Frank

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal

The paper introduces software that optimizes transcription factor networks to buffer stochasticity and entrain to erratic circadian signals, finding multiple solutions that highlight the flexibility of overparameterized systems.

Optimization of transcription factor genetic circuits

This paper introduces a computational method to optimize transcription factor networks, demonstrating its ability to maintain circadian rhythms under stochastic perturbations.

Evolutionary design of regulatory control. II. Robust error-correcting feedback increases genetic and phenotypic variability

This paper develops a theory linking control theory and evolutionary dynamics to explain how robust regulatory systems accumulate genetic variability and phenotypic stochasticity.