Subgenomic satellite particle generation in recombinant AAV vectors results from DNA lesion/breakage and non-homologous end joining
Junping Zhang, Ping Guo, Xiangping Yu, Derek J. Pouchnik, Jenni Firrman, Hongying Wei, Nianli Sang, Roland W. Herzog, Yong Diao, Weidong Xiao
This study identifies DNA lesion/breakage and non-homologous end joining as the main mechanisms causing subgenomic satellite particle formation in recombinant AAV vectors.
bioRxiv · Aug 1, 2020 · PreprintMolecular Biology