Chenlin Xiu

This study evaluates an mRNA vaccine encoding CagW, a component of H. pylori's type IV secretion system, showing it protects mice against bacterial challenge.

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

This study integrates multi-omics data from Kp infection to identify an itaconate-centred metabolic-immune axis and a host-response signature with high diagnostic accuracy.

This study develops an mRNA-LNP vaccine targeting OmpX in KP, showing strong humoral and cellular immunity and complete protection in mice.

The paper reanalyzes public transcriptomic and metabolomic data to prioritize antigens for improved Brucella vaccines by integrating single-cell and metabolomic atlases.