Author

程宏献

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:metabolomics· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

Baihai Huang· 4 shared Chenlin XiuiD· 4 shared Lei He· 4 shared Shiyi Zhou· 4 shared Xiongxiong LuiD· 4 shared Yunwang ZhaoiD· 4 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

Baihai Huang

Mutual co-authors in cluster

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 31, 2026

Integrative multi-omics re-analysis of public sequencing and metabolomics repositories defines the mucosal immune and metabolic landscape of Helicobacter pylori infection and supports CagW as a rational mRNA-LNP vaccine antigen

Yunwang Zhao, 程宏献, Shiyi Zhou…·Xiongxiong Lu

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

DOI 10.64898/2026.10.30.763066

humanmouse

𝕏 PostBluesky

MicrobiologybioRxivPreprintOct 30, 2026

Integrative multi-omics decoding of the host response to Klebsiella pneumoniae infection reveals an itaconate-centred metabolic-immune axis and a spatially organised inflammatory programme

Yunwang Zhao, 程宏献, Shiyi Zhou…·Xiongxiong Lu

This study integrates multi-omics data from Kp infection to identify an itaconate-centred metabolic-immune axis and a host-response signature with high diagnostic accuracy.

DOI 10.64898/2026.10.29.762801

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintOct 26, 2026

An OmpX mRNA-LNP vaccine induces protective humoral and cellular immunity against Klebsiella pneumoniae in a C57BL/6 mouse model

Yunwang Zhao, 程宏献, Shiyi Zhou…·Xiongxiong Lu

This study develops an mRNA-LNP vaccine targeting OmpX in KP, showing strong humoral and cellular immunity and complete protection in mice.

DOI 10.64898/2026.10.26.761762

mousestatistical model

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 24, 2026

Integrative reanalysis of public intracellular and vaccine-challenge transcriptomes, informed by single-cell and metabolomic atlases, refines antigen prioritisation for next-generation veterinary Brucella vaccines

Yunwang Zhao, 程宏献, Shiyi Zhou…·Xiongxiong Lu

The paper reanalyzes public transcriptomic and metabolomic data to prioritize antigens for improved Brucella vaccines by integrating single-cell and metabolomic atlases.

DOI 10.64898/2026.10.19.760311

mousebulk RNA-seq

𝕏 PostBluesky