Spaceland: Histology-Guided Reconstruction of High-Resolution Whole-Organ 3D Molecular Atlases from Sparse Spatial Transcriptomics
Fangfang Xu, Zhenfeng Zhuang, Yun Zhu, Bo Ying, Naiqiao Hou, Weiping Lin, Liansheng Wang, Chaoyong James Yang, Jia Tao Song
Spaceland reconstructs high-resolution 3D molecular atlases from sparse spatial transcriptomics and histology, improving resolution and accuracy across multiple biological contexts.
bioRxiv · Jul 27, 2026 · PreprintBioinformatics