Author

David Hirst

InsermORCID 0000-0001-7574-5531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Anaı̈s BaudotiD· 2 shared Bruno ReversadeiD· 1 shared Camille DioniD· 1 shared Camille LaberthonnìèreiD· 1 shared Frédérique MagdinieriD· 1 shared Jérôme D. RobiniD· 1 shared Jérôme DéjardiniD· 1 shared José Adélaı̈deiD· 1 shared

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2021-2025 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

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2 papers

Recent·Most cited

BioinformaticsGenome biologyPeer-reviewedJul 25, 2025

MOTL: enhancing multi-omics matrix factorization with transfer learning

David P. Hirst, Morgane Térézol, Laura Cantini…·Anaı̈s Baudot

MOTL improves multi-omics data factorization for small datasets by transferring knowledge from large datasets, enhancing cancer subtype identification in glioblastoma samples.

6 citations

humanmultiome

𝕏 PostBluesky

GeneticsbioRxivPreprintMay 17, 2021

SMCHD1 variants may induce variegated expression in Facio Scapulo Humeral Dystophy and Bosma Arhinia and microphtalmia syndrome

Camille Laberthonnìère, Raphaël Chevalier, Camille Dion…·Frédérique Magdinier

The paper investigates SMCHD1's role in two genetic syndromes, showing it regulates chromatin and gene expression through DNA methylation and chromatin organization.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky