Author

Ayan Bhattacharjee

University of PennsylvaniaORCID 0000-0001-7665-5554Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Gregory R. BowmaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

1 paper

Recent·Most cited

BiophysicsThe Journal of Physical Chemistry BPeer-reviewedJul 29, 2025

Pathogenic BRCA1 mutations disrupt allosteric control by BARD1

Ayan Bhattacharjee, Gregory R. Bowman

This study investigates how pathogenic BRCA1 mutations disrupt BARD1-mediated allosteric control, revealing conformational changes that impair E3 ligase activity and contribute to cancer.

DOI 10.1021/acs.jpcb.5c03653

humanprotein structure

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