Koichi Akashi

Epidermal NLRP1, PYCARD and CASP4 versus dermal GSDMD polarity in systemic sclerosis skin is reproduced by same-donor cell-class pseudobulk for PYCARD and GSDMD, but rarely NLRP1.

The paper compares GSDMD transcript levels between endothelial and cardiomyocyte compartments across three human heart cohorts, finding consistently higher levels in endothelial cells.

This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.