Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation
Jiawen Chen, Aneri Patel, Mohammad Mir, Maria R. Hudock, Meghan R. Pinezich, Brandon A. Guenthart, Matthew D. Bacchetta, Gordana Vunjak‐Novakovic, Jin-Ho Kim
This study uses mechanical oscillation to enhance endosomal escape of mRNA delivered by lipid nanoparticles, improving transfection efficiency without harming cell viability or organelle integrity.
Advanced Healthcare Materials · Oct 23, 2024Peer-reviewedBioengineering