Disentangling genetic feature selection and aggregation in transcriptome-wide association studies
Chen Cao, Pathum Kossinna, Devin Kwok, Qing Li, Jingni He, Liya Su, Xingyi Guo, Qingrun Zhang, Quan Long
This paper shows that combining feature selection and aggregation in GReX limits TWAS power and adaptability, especially with low expression heritability.
Genetics · Nov 27, 2021Peer-reviewedBioinformatics