Systems BiologybioRxivPreprint
Experimental and stochastic models of melanoma T-cell therapy define impact of subclone fitness on selection of antigen loss variants
Nicole Glodde, Anna Kraut, Debby Konijnenberg…·Michael Hölzel
The paper shows that genetic antigen loss in melanoma cells is selected for under T-cell therapy due to subclone fitness differences and stochastic events.
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