Experimental and stochastic models of melanoma T-cell therapy define impact of subclone fitness on selection of antigen loss variants
Nicole Glodde, Anna Kraut, Debby Konijnenberg, Saskia Vadder, Florian Kreten, Jonathan Leo Schmid-Burgk, Pia Aymans, Kai Echelmeyer, Martin Rumpf, Jennifer Landsberg, Tobias Bald, Thomas Tüting, Anton Bovier, Michael Hölzel
The paper shows that genetic antigen loss in melanoma cells is selected for under T-cell therapy due to subclone fitness differences and stochastic events.
bioRxiv · Nov 30, 2019 · PreprintSystems Biology