Sakari Jukarainen

The paper uses genome-wide meta-analysis and machine learning to study prescription opioid use in 860,000 individuals, identifying genetic loci and distinguishing between pain-related and dose-intensity traits.

The paper identifies a regulatory variant in IRF6 associated with increased cleft palate risk in Finland and shows it disrupts IRF6 enhancer function.

This study estimates the impact of genetic risk factors on disease burden using disability-adjusted life years (DALYs) and finds that both common and rare variants significantly contribute to healthy life years lost.