PhysiologyJournal of Lipid ResearchPeer-reviewed
Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs
Yanjun Jiang, Zhengfeng Fang, Gregory J. Guthrie…·Douglas G. Burrin
The study shows that enteral OCA prevents cholestasis and intestinal atrophy in neonatal pigs by enhancing bile acid and sterol transport through FXR target genes, with additional intestinal growth benefits.
6 citations