Michael B. Ghadimi

Deep proteomics of 997 treatment-naïve colorectal cancers defines six subgroups, splitting chromosomally unstable tumors into three and revealing a rare adverse subgroup, with H&E slide benchmarks.

This study identifies ADRA2A as a gene that promotes the classical/progenitor subtype and reduces aggressiveness in pancreatic cancer by altering transcriptome and metabolome profiles.