Author

Sean D. Quigley

ORCID 0000-0001-8212-4725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:transformer / foundation model· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Adrian Lange· 1 shared Andrew L. FergusoniD· 1 shared Anthony Beardsworth CostaiD· 1 shared Claire M. BuchananiD· 1 shared Clayton M. DilksiD· 1 shared David J. Hosfield· 1 shared Emre Sevgen· 1 shared Jeff Mayer· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperSynthetic Biology

Adrian Lange

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1 paper

Recent·Most cited

Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewedOct 6, 2025

ProT-VAE: Protein Transformer Variational AutoEncoder for Functional Protein Design

Emre Sevgen, Joshua Moller, Adrian Lange…·Andrew L. Ferguson

ProT-VAE designs functional proteins by learning sequence-function relationships using a transformer-based variational autoencoder, enabling conditional generation of novel sequences with high functionality.

54 citationstop 1%

protein sequencevariational autoencoder

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