Clayton M. Dilks

Global genomic diversity of the selfing nematode Caenorhabditis tropicalis correlates with geography

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

Caenorhabditis briggsae ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

ProT-VAE: Protein Transformer Variational AutoEncoder for Functional Protein Design

ProT-VAE designs functional proteins by learning sequence-function relationships using a transformer-based variational autoencoder, enabling conditional generation of novel sequences with high functionality.

Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independent of beta-tubulin

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

Praziquantel inhibits Caenorhabditis elegans development and species-wide differences might be cct-8-dependent

This study investigates praziquantel's effects on C. elegans development and identifies potential genetic factors, including cct-8, that influence susceptibility.

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans strains

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.

Interactions of C. elegans -tubulins with the microtubule inhibitor albendazole

The paper investigates the role of C. elegans β-tubulin genes in albendazole resistance, finding that tbb-2 modifies sensitivity and ben-1 mutations primarily confer resistance.

Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles

This study identifies four new beta-tubulin alleles in parasitic nematodes that confer resistance to benzimidazoles and show no significant fitness costs.

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

This study demonstrates that five beta-tubulin alleles confer benzimidazole resistance in parasitic nematodes and shows that E198V reduces fitness in the absence of the drug.