BioinformaticsProteins Structure Function and BioinformaticsPeer-reviewed
Role of Mutual Information Profile Shifts in Assessing the Pathogenicity of Mutations on Protein Functions: The Case of Pyrin Variants Associated with Familial Mediterranean Fever
Aysima Hacisuleyman, Ahmet Gül, Burak Erman
This paper introduces a method using mutual information profile shifts to assess the pathogenicity of Pyrin mutations in familial Mediterranean fever, showing how negative shifts indicate severe functional effects.
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