Sérgio Amorim de Alencar

The paper assesses the impact of missense mutations on human LL-37 structure and antimicrobial activity using computational methods, finding some mutations may reduce activity and contribute to inflammatory diseases.

The paper investigates the structural effects of two rare point mutations in amylin, finding both mutations affect aggregation potential and suggest therapeutic implications for type II diabetes.

The paper evaluates 20 SNP prediction tools on CYP2D6 missense variants, finding FATHMM performs best with a Matthews correlation coefficient of 0.39.