Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization
Chloé Dias, Nissrine Ballout, Guillaume Morla, Katia Alileche, Christophe Santiago, Ida Chiara Guerrera, Adeline Chaubet, Jérôme Ausseil, Stéphanie Trudel
This paper shows that abnormal heparan sulfate oligosaccharides from MPS III patients activate microglia to secrete EVs that impair neuronal dendritic arborization.
Molecular Medicine · Nov 4, 2024Peer-reviewedNeuroscience