Author

Derek W. Brown

National Cancer InstituteORCID 0000-0001-8393-1713Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:GWAS / association mapping· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Mitchell J. MachielaiD· 3 shared Alexander G. BickiD· 2 shared Andrea GannaiD· 2 shared Aoxing LiuiD· 2 shared Chikashi C. TeraoiD· 2 shared Eugene J. GardneriD· 2 shared Giulio GenoveseiD· 2 shared John R. B. PerryiD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Mitchell J. MachielaORCID

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3 papers

Recent·Most cited

GeneticsNature CommunicationsPeer-reviewedSep 8, 2023

Shared and distinct genetic etiologies for different types of clonal hematopoiesis

Derek W. Brown, Liam D. Cato, Yajie Zhao…·Mitchell J. Machiela

The paper identifies shared genetic architecture across different types of clonal hematopoiesis and finds that overlapping mutations increase hematological malignancy risk.

44 citationstop 2%

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJan 28, 2023

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection

Aoxing Liu, Giulio Genovese, Yajie Zhao…·Mitchell J. Machiela

This study identifies genetic drivers and cellular selection signatures of mosaic X chromosome loss in women using large-scale population data and polygenic scores.

7 citations

humanwhole-genome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 12, 2020

Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

Seyedeh Maryam Zekavat, Shu‐Hong Lin, Alexander G. Bick…·Pradeep Natarajan

The paper investigates the association between age-related mosaic chromosomal alterations and infection risk in 767,891 individuals without blood cancer, finding increased infection susceptibility linked to mCAs.

14 citations

humanwhole-genome sequencing

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