Chin‐Hsien Lin

The paper introduces FIDELITY, a method for rapid cyclic immunolabeling of FFPE tissues, enabling multi-cycle protein profiling in intact specimens.

This study identifies pathogenic and intermediate repeat expansions in Parkinson's disease and parkinsonism across 11 ancestries, highlighting ATXN2's role in PD risk and ancestry-specific patterns.

This study investigates the role of SORL1 genetic variants in AD, RD, and PD across diverse populations, identifying variants associated with risk but no significant cumulative effect.

The paper investigates how phosphorylation of DNAJB6b by YES kinase affects tau protein aggregation in Alzheimer's disease, suggesting it may contribute to disease risk and identify a potential biomarker.

The paper assesses the frequency of dystonia-linked pathogenic variants in Parkinson's disease patients and finds they are present in 0.57% of cases, with GCH1 being the most common gene affected.

The paper identifies the LRRK2 p.A419V variant as a significant risk factor for Parkinson's disease in East Asian populations and explores its association with age of onset.

The paper validates a mitochondrial polygenic score for Parkinson's disease across diverse populations, finding strong associations in Europeans and Ashkenazi Jews but not in other ancestries.

This paper introduces HIF-Clear, a method for clearing and labeling FFPE brain specimens, enabling analysis of neuronal circuitry in whole brains.