Evolutionary BiologybioRxivPreprint
Uncertainty in joint Ancestral State Reconstruction: Improving accuracy and biological interpretability of ancestral state prediction
James D. Boyko, Kyle J. Gontjes, Evan S. Snitkin, Stephen A. Smith
This paper improves ancestral state reconstruction by introducing joint reconstructions and uncertainty quantification, showing higher accuracy and biological insights in antibiotic resistance evolution.
DOI 10.1101/2025.10.09.681367