The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations
Joshua S. Weinstock, Sharjeel A. Chaudhry, Maria Ioannou, Maria Viskadourou, Paula Reventún, Yasminka A. Jakubek, L. Alexander Liggett, Cecelia A. Laurie, Jai Broome, Alyna Khan, Kent D. Taylor, Xiuqing Guo, Patricia A. Peyser, Eric Boerwinkle, Nathalie Chami, , Marios Arvanitis
The paper develops a method to quantify somatic mutation burden in whole-genome sequencing data without paired-tissue samples and identifies genetic and phenotypic correlates of clonal hematopoiesis without known driver mutations.
medRxiv · Aug 22, 2024 · PreprintGenetic & Genomic Medicine