Author

Maria Ioannou

Johns Hopkins UniversityORCID 0009-0004-8677-7589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Abiola Abdulrahman AyanlajaiD· 1 shared Albert V. SmithiD· 1 shared Alex P. ReineriD· 1 shared Alexander G. BickiD· 1 shared Alexis J. BattleiD· 1 shared Alyna KhaniD· 1 shared Aurelian BidulescuiD· 1 shared Bernhard HaringiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Abiola Abdulrahman AyanlajaORCID

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2 papers

Recent·Most cited

Combined inhibition of SHP2 overcomes adaptive resistance to type 1 BRAF inhibitors in BRAF V600E-driven high-grade glioma

Abiola Abdulrahman Ayanlaja, Michael Chang, Kriti Lalwani, Maria Ioannou, Jiawan Wang, Shreya Jagtap, Yanbo Yang, Calixto‐Hope G. Lucas, Jean M. Mulcahy Levy, Robyn D. Gartrell, Christine A. Pratilas, Karisa C. Schreck

This study shows that combining SHP2 inhibition with BRAF inhibitors overcomes resistance in BRAF V600E-driven gliomas by suppressing RAS/ERK signaling and preventing tumor growth.

Neuro-Oncology Advances · Jan 1, 2025Peer-reviewedCancer Biology

The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations

Joshua S. Weinstock, Sharjeel A. Chaudhry, Maria Ioannou, Maria Viskadourou, Paula Reventún, Yasminka A. Jakubek, L. Alexander Liggett, Cecelia A. Laurie, Jai Broome, Alyna Khan, Kent D. Taylor, Xiuqing Guo, Patricia A. Peyser, Eric Boerwinkle, Nathalie Chami, , Marios Arvanitis

The paper develops a method to quantify somatic mutation burden in whole-genome sequencing data without paired-tissue samples and identifies genetic and phenotypic correlates of clonal hematopoiesis without known driver mutations.

medRxiv · Aug 22, 2024 · PreprintGenetic & Genomic Medicine