Yupeng Chen

This study identifies DPF3a as a chromatin remodeler that regulates myogenesis through three-dimensional genome organization rather than local chromatin accessibility.

The paper develops DeepAnchor, a deep learning model to characterize CTCF binding patterns and predict CTCF-anchored loops across human tissues, revealing sequence and chromatin features that influence loop formation and disease mechanisms.

The paper identifies causal regulatory elements in complex genetic loci using CRISPR perturbations and shows that many causal variants lack classical epigenetic markers.