Lindsey Guan

The paper evaluates how AlphaFold2-Multimer, AlphaFold3, Boltz-1, and Chai-1 predict protein-peptide complex structures using experimentally resolved datasets, finding biases and insights into MSA usage.

FLIGHTED improves protein fitness model performance by accounting for experimental noise in high-throughput data, showing that data size and architecture matter more than model scale.