Patrice Duroux

Therapeutic Monoclonal Antibodies Repurposing in Oncology via IMGT/mAb-KG Embeddings

The paper develops a knowledge graph embedding tool for mAb repurposing in oncology, identifying two mAbs for clinical trials.

Novel Genes and Polymorphisms in Human Immunoglobulin Light Chains Across Diverse Populations Through Comprehensive IMGT(R) Analysis

IMGT(R) at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis

The paper introduces new automated and scalable tools for immune locus analysis, enhancing genomic data access, repertoire analysis, and peptide-MHC prediction through FAIR data principles.

Identification of Engineered IMGT Fc Variants in IMGT/mAb-DB Therapeutic Antibodies and Fusion proteins

The paper identifies engineered Fc variants in therapeutic antibodies and fusion proteins using the IMGT/FcVariantsExplorer tool and integrates the findings into IMGT/mAb-DB.

IMGT(R) Analysis of the Human IGH Locus: Unveiling Novel Polymorphisms and Copy Number Variations in Genome Assemblies from Diverse Ancestral Backgrounds

The paper analyzes the human IGH locus across 15 genome assemblies to identify novel alleles, copy number variations, and polymorphisms, enhancing the IMGT(R) reference directory.

IMGT/RobustpMHC: Robust Training for class-I MHCPeptide Binding Prediction

The paper introduces RobustpMHC, a self-supervised learning method for peptide-MHC class I binding prediction, showing improvements over existing approaches across multiple datasets.