Modulation of CIP2A dimerization and protein stability via druggable pocket
Karolina Pavic, Paola Moyano-Gómez, Pekka Roivas, Sami T. Kurkinen, Hanna Parkkola, Linda Kauppinen, Sanna Rauhamäki, Aleksi Lehtinen, Petja Rosenqvist, Pasi Virta, Ulla Pentikäinen, Olli T. Pentikäinen, Jukka K. Westermarck
This study identifies a druggable pocket on CIP2A that modulates its dimerization, PP2A interaction, and stability, with GNA as a tool compound that disrupts these functions.
bioRxiv · Oct 13, 2025 · PreprintBiochemistry