BioinformaticsScientific ReportsPeer-reviewed
Prediction and interpretation of deleterious coding variants in terms of protein structural stability
François Ancien, Fabrizio Pucci, Maxime Godfroid, Marianne J. Rooman
The paper develops a stability-driven classifier to predict deleterious coding variants based on protein structural stability, achieving 71% balanced accuracy and 89% positive predictive value.
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