Author

Hui Guan

University of Massachusetts AmherstORCID 0000-0001-9128-2231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

Jian Wen HuangiD· 1 shared Jianhan CheniD· 1 shared Shrishti Barethiya· 1 shared Xiao LiuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBioinformatics

Jian Wen HuangORCID

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1 paper

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BioinformaticsbioRxivPreprintNov 9, 2025

Overcoming Extrapolation Challenges of Deep Learning by Incorporating Physics in Protein Sequence-Function Modeling

Shrishti Barethiya, Jian Wen Huang, Xiao Liu…·Jianhan Chen

This paper improves deep learning models for protein sequence-function prediction by integrating physical principles to enhance extrapolation performance.

DOI 10.1101/2025.11.09.687530

protein sequenceprotein structure

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