Jian Wen Huang

This paper uses topology-based modeling to study the binding and folding of WNV NS2B/NS3 protease and shows how the G4SG4 linker affects its stability and folding pathways.

This study uses simulations to analyze CheA domain interactions and identifies dynamic modes that may facilitate autophosphorylation.

This paper improves deep learning models for protein sequence-function prediction by integrating physical principles to enhance extrapolation performance.

The paper predicts single point mutations in SARS-CoV-2 RBD that enhance binding affinity to hACE2 using in silico methods and validates them with SPR assays.