Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer
Dorothy M. Chen, Ruocheng Dong, Linda Kachuri…·Rebecca E. Graff
Author
Division of Cancer Epidemiology and GeneticsORCID 0000-0001-9252-1492Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
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Dorothy M. Chen, Ruocheng Dong, Linda Kachuri…·Rebecca E. Graff
Thomas J. Hoffmann, Rebecca E. Graff, Ravi Madduri…·John S. Witte
This study identifies 447 new genetic variants associated with prostate-specific antigen levels across multiple ancestries and shows improved cross-ancestry prediction of PSA, with implications for personalized prostate cancer screening.
Linda Kachuri, Thomas J. Hoffmann, Yu Jiang…·John S. Witte
This study develops a polygenic score to adjust PSA levels, improving the detection of aggressive prostate cancer while reducing unnecessary biopsies.