BioinformaticsNucleic Acids ResearchPeer-reviewed
Characterization and decontamination of background noise in droplet-based single-cell protein expression data with DecontPro
Yuan Yin, Masanao Yajima, Joshua David Campbell
The paper identifies and removes background noise in CITE-seq data using DecontPro, a Bayesian model that improves clustering specificity and reduces contamination from spongelets and ambient ADTs.