Author

Samuel J. Dettmer

University of BirminghamORCID 0000-0001-9262-976XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Michael J. HannoniD· 2 shared Hannah M. P. Stock· 1 shared Hugo D. WilliamsiD· 1 shared Sumit BajpaiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBiophysics

Michael J. HannonORCID

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2 papers

Recent·Most cited

A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for DNA Three-Way Junctions by Induced-Fit

Hugo D. Williams, Samuel J. Dettmer, Sumit Bajpai, Michael J. Hannon

This paper describes a quadruple-stranded helicate that preferentially binds DNA three-way junctions over four-way junctions, revealing the importance of size and shape in junction recognition.

Journal of the American Chemical Society · Oct 22, 2025Peer-reviewedBiophysics

Interactions of Elongated Dinuclear Metallo-Cylinders with DNA Three-Way and Four-Way Junctions

Samuel J. Dettmer, Hannah M. P. Stock, Michael J. Hannon

This paper shows that a longer metallo-cylinder binds selectively to DNA three-way and four-way junctions, with simulations revealing two metastable conformations.

JBIC Journal of Biological Inorganic Chemistry · Sep 15, 2025Peer-reviewedBiophysics