Extracellular Vesicles of Salivary Mesenchymal Stem Cells Mitigate Acute Irradiation Injury: Use of an ex-vivo organotypic human slice tissue culture as a disease model
Akshaya Upadhyay, Migmar Tsamchoe, Anthony G. Zeitouni, Jordan Gigliotti, Junzheng Peng, Mahdokht Mahmoodi, Haider Abo Sharkh, Nicholas Maroun Makhoul, Michel El‐Hakim, Jiangping Wu, Simon D. Tran
The paper develops an ex vivo model of salivary gland damage from IR and identifies extracellular vesicles from MSCs as effective in reducing IR-induced damage markers.
bioRxiv · Sep 4, 2025 · PreprintMolecular Biology