NeurosciencePLoS GeneticsPeer-reviewed
Spinal cord extracts from sporadic ALS induce and propagate TDP-43 pathology in cerebral organoids
Yoshitaka Tamaki, Jay P. Ross, Paria Alipour…·Guy Armand Rouleau
The paper shows that spinal cord extracts from sporadic ALS patients induce and spread TDP-43 pathology in human cerebral organoids, mimicking ALS pathophysiology.
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