Javier de la Fuente

Genomic Taxometric Analysis of Negative Emotionality and Major Depressive Disorder Highlights a Gradient of Genetic Differentiation across the Severity Spectrum

The paper introduces GTACCC to assess genetic continuity and differentiation of negative emotionality and MDD across severity, finding increasing genetic sharing with severity.

Pervasive Downward Bias in Estimates of Liability Scale Heritability in GWAS Meta-Analysis: A Simple Solution

The paper shows that standard methods for liability-scale heritability estimation in GWAS meta-analysis can be downwardly biased and proposes a simple correction based on effective sample size summation.