Peter A. Merkel

This study identifies two genome-wide significant genetic associations with EGPA, one in SSH2 and one in RUNX1, and shows colocalization with molecular traits related to IL5RA and LYN.

MultiPLIER uses transfer learning from large public data to improve analysis of small rare disease datasets by capturing systemic biological features.

The paper identifies shared molecular pathways between ANCA-associated vasculitis and nephrotic syndrome, highlighting JAK-STAT signaling as a potential therapeutic target.