Benjamin A. Raby

This paper identifies compartment- and cell-specific molecular programs in preclinical familial pulmonary fibrosis using multi-omic profiling and finds these signatures are partially represented in peripheral blood.

This study identifies two genome-wide significant genetic associations with EGPA, one in SSH2 and one in RUNX1, and shows colocalization with molecular traits related to IL5RA and LYN.

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

The paper identifies smooth muscle Cxcl12 activation as a contributor to vascular remodeling in flow-induced pulmonary hypertension using a new murine model.

The paper validates novel telomere length regulation genes POP5 and KBTBD6 identified through trans-ancestry GWAS using functional experiments in blood cells.

This study identifies 59 sentinel variants and two novel genes associated with telomere length using whole genome sequences from 109,122 trans-ethnic individuals.

This study uses single-cell RNA-seq to identify aberrant cell populations in IPF lungs, revealing novel basaloid cells and vascular endothelial changes.

The paper identifies peripheral and core genes in the human interactome using gene expression data and shows their distinct biological roles and implications for disease classification and drug targets.

The paper identifies sex-specific gene expression changes in human myocardial tissue after ischemia, highlighting differences in pathways and cell-type proportions between males and females.

The paper uses gene co-expression networks in whole blood to identify molecular pathways associated with obese asthma, finding four modules linked to obesity and enriched for inflammatory pathways.

The paper develops a machine learning classifier for asthma using nasal RNA sequencing data, achieving high accuracy across multiple test sets.