Biomineralization from platelet δ-granules as the origin of cardiovascular calcification in humans and other animals.
Sérgio Bertazzo, Elena Tsolaki, Shweta Agarwal, Najma Latif, Ann M. McCormack, Padmini Sarathchandra, Magdi Habib Yacoub, Inge Katrin Herrmann, Ken Smith, Janice C S Tsui, Adrian H. Chester
The paper identifies platelet δ-granules as the origin of calcified particles in cardiovascular tissue across mammals, birds, and lizards, proposing a new mechanism for cardiovascular calcification.
bioRxiv · Aug 6, 2026 · PreprintPathology