NeurosciencebioRxivPreprint
Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia Pathologies
Sonia Infante-Tadeo, Diane L. Barber
This paper shows that undifferentiated patient-derived iPSCs exhibit FTD hallmarks like lysosome dysfunction and TDP-43 proteinopathy, and identifies dysregulated genes related to neurodegeneration.
DOI 10.1101/2024.12.11.628042