Microfluidic T-Chip enables one-step clinical-scale T-cell purification from blood products for CAR T-cell manufacturing
Maheen Rana, Sophia E. Nigrovic, Adriana Payan-Medina, Sarthak Saha, Victor R. Putaturo, Quinn E. Cunneely, Remy Bell, Ezgi Antmen, Marcela Valderrama Maus, Mehmet Toner, Magdi Elsallab, Avanish Mishra
The paper introduces a microfluidic T-Chip for one-step clinical-scale T-cell purification from blood products, achieving high purity, viability, and recovery of CD3+ T cells for CAR T-cell manufacturing.
bioRxiv · Jul 31, 2026 · PreprintBioengineering