Gordon Qian

The paper analyzes mitochondrial DNA variation in a healthy older cohort, identifies pathogenic variants, and proposes improved heteroplasmy thresholding to reduce false positives.

The paper assesses mitochondrial disease variants and genome constraint in healthy older adults, finding no significant phenotype associations but suggesting constraint measures may relate to aging biomarkers.

The paper evaluates MAG pipelines using MAG-E, revealing performance gaps in assembly, binning, and quality control for the human gut microbiome.

This study examines the association between gut microbiome diversity and 24-hour blood pressure variability, identifying sex-specific bacterial species linked to systolic and diastolic blood pressure fluctuations.

The paper identifies coverage bias at transcription start sites in metagenomic data that correlates with gene expression, independent of GC bias and sequencing artifacts.

MetaQuad identifies shared polymorphic variants in metagenomic samples using density-based clustering, reducing false positives while maintaining true-positive rates.

GEOracle identifies perturbation gene targets in GEO by mining free text metadata and performing differential expression analysis.