Type 1 diabetes genome-wide association analysis with imputation identifies five new risk regions
Nicholas J. Cooper, Chris Wallace, Oliver S. Burren…·John A. Todd
Author
University of CambridgeORCID 0000-0001-9796-7688Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Nicholas J. Cooper, Chris Wallace, Oliver S. Burren…·John A. Todd
Daniel B. Rainbow, Marcin Pekalski, Antony J. Cutler…·Linda S. Wicker
The paper identifies SNP rs61839660 as the causal variant for autoimmunity by showing its loss reduces IL2RA expression and T1D protection.
The paper argues that de-identification does not guarantee anonymity and warns against extending data-sharing policies based on this misconception.
Chris Wallace, Antony J Cutler, Nikolas Pontikos…·Linda Wicker
This study uses a Bayesian stochastic search method to fine map genetic variants in the IL-2RA region associated with multiple sclerosis and type 1 diabetes, identifying shared causal variants.
Mary D Fortune, Hui Guo, Oliver Burren…·Chris Wallace
The paper identifies shared and distinct genetic risk variants across four autoimmune diseases using colocalization methods with shared control data, revealing novel associations and complex patterns.