chromMAGMA identifies candidate risk genes for epithelial ovarian cancer by mapping risk variants to noncoding regulatory elements, revealing new genes and pathways involved in the disease.

bioRxiv · Jan 21, 2022 · PreprintGenetics

A cellular and molecular portrait of endometriosis subtypes

Marcos A. Fonseca, Kelly Nicole Wright, Xianzhi Lin, Forough Abbasi, Marcela Haro, Jennifer K. Sun, Lourdes Hernández, Natasha L. Orr, Jooyoon Hong, Yunhee Choi-Kuaea, Horacio Maluf, Bonnie Lei Balzer, Ilana A. Cass, Mireille Truong, Yemin Wang, , Kate Lawrenson

This study profiles single-cell transcriptomes of endometriosis subtypes to identify transcriptional differences and associations with ovarian cancer.

bioRxiv · May 20, 2021 · PreprintGenomics

Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian Tube

Huy Q. Dinh, Xianzhi Lin, Forough Abbasi, Robbin A. Nameki, Marcela Haro, Claire E. Olingy, Heidi S. Y. Chang, Lourdes Hernández, Simon A. Gayther, Kelly Nicole Wright, Paul-Joseph P. Aspuria, Beth Y. Karlan, Rosario I. Corona, Andrew Li, B.J. Rimel, , Kate Lawrenson

This study uses single-cell transcriptomics to identify gene expression networks in the human fallopian tube, revealing epithelial subtypes and their role in cancer progression.

Cell Reports · Apr 1, 2021Peer-reviewedGenomics

In vivo discovery of RNA proximal proteins in human cells via proximity-dependent biotinylation

Xianzhi Lin, Marcos A. Fonseca, Rosario I. Corona, Kate Lawrenson

This paper introduces RPL, a method to identify RNA-proximal proteins in human cells using CRISPR-Cas13b and APEX2, revealing new insights into RNA interactions and subcellular localization.

bioRxiv · Feb 28, 2020 · PreprintMolecular Biology