Molecular BiologybioRxiv
Deficiency of nucleotide excision repair explains mutational signature observed in cancer
Myrthe Jager, Francis Blokzijl, Ewart Kuijk…·Edwin P. J. G. Cuppen
The paper shows that NER deficiency increases Signature 8 mutations in specific tissues and suggests this could be a biomarker for NER-deficiency in cancer.