Author

Frederick Xu

University of PennsylvaniaORCID 0000-0001-9877-0481Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

Duy Anh Duong-TraniD· 3 shared Li SheniD· 3 shared Yize ZhaoiD· 3 shared Sumita GaraiiD· 2 shared Alan David KaplaniD· 1 shared Andrew J. SaykiniD· 1 shared Christos A. DavatzikosiD· 1 shared Enrico AmicoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Duy Anh Duong-TranORCID

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3 papers

Recent·Most cited

Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-β Spread in Alzheimer's Disease

Frederick Xu, Duy Duong-Tran, Heng Huang, Andrew J. Saykin, Paul M. Thompson, Christos A. Davatzikos, Yize Zhao, Li Shen, the Frontotemporal Lobar Degeneration Neuroimaging Initiative

This study improves modeling of amyloid-β spread in Alzheimer's Disease using a gene-modulated network diffusion framework, showing better performance in correlation and replicability across cohorts.

bioRxiv · May 7, 2026 · PreprintBioinformatics

Quantifying Contributions from TopologicalCycles in the Brain Network towards Cognition

Sumita Garai, Sandra Vo, Lucy Blank, Frederick Xu, Jiong Chen, Duy Anh Duong-Tran, Yize Zhao, Li Shen

This study introduces H-VIP to quantify vertex contributions to topological cycles in brain networks and finds a positive correlation with cognitive measures in both structural and functional connectomes.

bioRxiv · Jun 3, 2024 · PreprintBioinformatics

Homological landscape of human brain functional sub-circuits

Duy Anh Duong-Tran, Ralph M. Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick H. Xu, Jingxuan Bao, Enrico Amico, Alan David Kaplan, Giovanni Petri, Joaquín Goñi, Yize Zhao, Li Shen

The paper introduces a homological formalism to analyze higher-order properties of human brain functional sub-circuits and identifies task-specific homological differences in brain connectivity.

Mathematics · Jan 31, 2024Peer-reviewedNeuroscience