Author

Lei Duan

Sichuan UniversityORCID 0000-0001-9965-4618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:contrastive learning· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

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Chengxin HeiD· 1 shared Huiru ZhengiD· 1 shared Runze MaiD· 1 shared Zhongyue ZhangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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1 shared paperBioinformatics

Chengxin HeORCID

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1 paper

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BioinformaticsbioRxivPreprintNov 11, 2025

Integrating Millions of Years of Evolutionary Information into Protein Structure Models for Function Prediction

Runze Ma, Chengxin He, Zhongyue Zhang…·Lei Duan

This paper introduces ESMSCOP, a contrast-aware pre-training framework that integrates evolutionary and structural information for improved protein function prediction.

DOI 10.1101/2025.11.11.687944

protein sequencecontrastive learning

𝕏 PostBluesky